Fig. 3

Higher WMHV is associated with clinical dementia outcomes over two years among females but not males. A.) A significant interaction effect between WMHV and visit time on CDR sum of boxes was observed for females in a linear mixed effect model. The predicted slopes for a participant with a mean and +- 1 standard deviation of WMHV for females is plotted. B.) The predicted slopes for a participant with a mean and +- 1 standard deviation of WMHV for males is plotted. There was no observed interaction effect between WMHV and visit time on CDR sum of boxes score for males Follow-up visits were acquired approximately one year after the prior visit. WMHV = white matter hyperintensity volume