Table 1 Participant characteristics

Age

72.3 (7.44)

72.8 (7.59)

-0.93^a

0.35

Participants aged < = 65 years old (%)

49 (20.3%)

87 (18.4%)

0.26^b

0.61

Years of Education

10.4 (4.74)

7.04 (4.54)

9.04^a

< 0.001

BMI^a

23.9 (3.03)

24.0 (3.31)

-0.41^a

0.68

HbA_1c^b, % mmol/mol

6.12 (1.04)

5.98 (0.89)

-1.80^a

0.073

log(TSH)^c, mIU/L

0.51 (0.82)

0.46 (0.97)

-0.78^a

0.43

log(Homocysteine)^d, umol/L

2.69 (0.445)

2.50 (0.36)

-5.57^a

< 0.001

Global 18 F-flutemetamol SUVR^e

0.68 (0.15)

0.67 (0.15)

-0.93^a

0.35

‡APOE ɛ4 positive, N (%)

80 (33.2%)

135 (28.6%)

1.39^b

0.24

Hypertension, N (%)

132 (54.8%)

256 (54.2%)

0.0031^b

0.96

Diabetes, N (%)

67 (27.8%)

93 (19.7%)

5.6^b

0.018

Smoker, N (%)

152 (63.1%)

23 (4.9%)

288.64^b

< 0.001

Cognitive Diagnosis, n (%)

1.38^b

0.50

No cognitive decline

n = 5 (2.1%)

n = 5 (1.1%)

MCI

n = 138 (57.3%)

n = 281 (59.5%)

Dementia

n = 98 (40.7%)

n = 186 (39.4%)

Cardiovascular Risk Factors

Pulse Pressure, mmHg

75.8 (12.4)

76.0 (11.6)

-0.24^a

0.81

Systolic Blood Pressure, mmHg

130.7 (17.3)

134.6 (19.3)

-2.71^a

0.0070

Diastolic Blood Pressure, mmHg

76.0 (12.1)

76.7 (11.5)

-0.70^a

0.48

LDL-C, mg/dL

92.7 (33.3)

104 (38.8)

4.10^a

< 0.001

HDL-C, mg/dL, M (SD)

51.6 (14.1)

58.3 (14.8)

5.89^a

< 0.001