Table 2 The interaction between sex with age, diabetes status is associated with WMHV. Multiple linear regression analysis tested for interaction effect with sex and known risk factors in relation to normalized white matter hyperintensity volume. Analysis controlled for scanner site and cognitive diagnosis and FDR multiple comparisons p-value correction was performed
| Â | WMHV | ||
|---|---|---|---|
|  | β (Std. error) | β 95% Confidence interval | Uncorrected p-value |
Age*Sex | -0.037 (0.011) | (-0.058, -0.016) | 0.00050 |
Hypertension*Sex | -0.15 (0.17) | (-0.48, 0.17) | 0.36 |
Diabetes*Sex | -0.52 (0.20) | (-0.91, -0.14) | 0.00079 |
log(HbA1c)*Sex | -1.55 (0.63) | (-2.78, -0.32) | 0.014 |
Pulse Pressure *Sex | -0.014 (0.0069) | (-0.028, -0.00068) | 0.040 |
Systolic BP *Sex | -0.0062 (0.0047) | (-0.016, 0.0031) | 0.19 |
log(Homocysteine) *Sex | -0.21 (0.21) | (-0.62, 0.21) | 0.33 |
log(TSH) *Sex | 0.17 (0.097) | (-0.025, 0.36) | 0.089 |
Diastolic BP *Sex | -0.0076 (0.0071) | (-0.022, 0.0065) | 0.29 |
APOE4 Status *Sex | 0.27 (0.18) | (-0.089, 0.63) | 0.14 |
HDL *Sex | 0.0064 (0.0060) | (-0.0054, 0.018) | 0.28 |
LDL *Sex | 3.7E-4 (0.0024) | (-0.0043, 0.0051) | 0.88 |
Global18F-flutemetamol SUVR *Sex | 0.30 (0.60) | (-0.88, 1.47) | 0.62 |
BMI *Sex | -0.0041 (0.027) | (-0.058, 0.050) | 0.88 |
Smoking Status *Sex | 0.10 (0.27) | (-0.42, 0.63) | 0.70 |