Fig. 4

Pharmacokinetics of single ascending dose AL002 in healthy volunteers. (A) Mean ± SD serum concentrations of AL002 (semi-logarithmic). LLOQ was 0.0200 µg/mL. (B) Mean ± SD CSF concentration of AL002 (semi-logarithmic). LLOQ was 5.0 ng/mL. n = 6 for the 6 mg/kg, 15 mg/kg, and 30 mg/kg dose groups; n = 5 for the 45 mg/kg group; n = 5–6 for 60 mg/kg group. Data for the 60 mg/kg dose at Day 57 are not shown, as n = 1. CSF, cerebrospinal fluid; LLOQ, lower limit of quantification; SD, standard deviation