Fig. 5

Pharmacodynamics of single ascending dose AL002 in CSF of healthy volunteers. (A-B) sTREM2, (C) SPP1 protein, (D) sCSF1R, and (E) IL1RN protein were measured in CSF samples collected at the indicated time points. Data are presented as unadjusted mean ± SD percent change from baseline. (A), (C), (D), and (E) n = 6 in placebo, 6 mg/kg, 15 mg/kg, 30 mg/kg cohorts; n = 5 in 45 mg/kg cohort; n = 5–6 in 60 mg/kg cohorts I and N. (B) In 60 mg/kg cohort N, n = 2 at Day 13, n = 5 at Day 30 and 43, n = 3 at Day 57. Nudging was used to differentiate overlapping datasets. CSF, cerebrospinal fluid; CSF1R, colony-stimulating factor 1 receptor; LLOQ, lower limit of quantification; NHP, nonhuman primate; sCSF1R, soluble CSF1R; SEM, standard error of the mean; sTREM2, soluble TREM2; TREM2, triggering receptor expressed on myeloid cells-2