Fig. 6

Pharmacodynamics of single ascending dose AL002 in plasma of healthy volunteers. (A) IL1RN protein and (B) sTREM2 were measured in plasma samples collected at the indicated time points. Data are presented as unadjusted mean ± SEM percent change from baseline. (A), (B), n = 11 in placebo, n = 3 in 0.003-0.2 mg/kg, n = 6 in each of 0.6 mg/kg, 2 mg/kg, 6 mg/kg, 15 mg/kg, 30 mg/kg, 45 mg/kg; n = 11–14 in 60 mg/kg cohorts I and N. EOI, end of injection; h, hours; SEM, standard error of the mean; sTREM2, soluble TREM2; TREM2, triggering receptor expressed on myeloid cells-2