Alzheimer's Research & Therapy

Table 1 Mean toxicokinetic parameters for AL002 in cynomolgus monkeys in the 4-week GLP study

From: Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease

Dose	Day	C_max, µg/mL	Clearance, mL/h/kg	AUC_{0 − 168}, h●µg/mL
20 mg/kg^a	1	401	NA	25,800
20 mg/kg^a	22	504	0.615	33,700
80 mg/kg^a	1	1590	NA	82,100
80 mg/kg^a	22	1560	0.811	99,400
250 mg/kg^b	1	4430	NA	219,000
250 mg/kg^b	22	5130	0.976	265,000

^an = 6 (3 male, 3 female)
^bn = 10 (5 male, 5 female)
AUC_{0 − 168}, area under the concentration-time curve from time zero to 168 h; C_max, maximum concentration; GLP, good laboratory practice; NA, not available

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ISSN: 1758-9193

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