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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites

Fig. 1

Analysis design. mtDNA-CN = mitochondria DNA copy number; ADSP = Alzheimer’s Disease Sequencing Project; WGS = whole genome sequencing; AD = Alzheimer disease; EA = European Ancestry, AA = African American, CH = Caribbean Hispanic; ADNI = Alzheimer’s Disease Neuroimaging Initiative; MCI = mild cognitive impairment; GWAS = genome-wide association study; * Covariates include age, sex, genetic ancestry group, APOE ε2 and ε4 dosage, sequencing center, and PCR. ** Covariates include age, sex, and original study phase; *** Covariates include age, sex, original study phase, and AD diagnosis; # Cox proportional hazards regression model: \(log\,h(t){\sim}adjusted\,blood\,mtDNA-CN+age+sex+original\,study\,phase\)

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Alzheimer's Research & Therapy

ISSN: 1758-9193