Fig. 2

Partial residuals plots showing the relationships between blood mtDNA-CN from ADNI and AD diagnosis (A), age (B), sex (C). Residuals were calculated after fitting a liner model where mtDNA-CN was the dependent variable and age, sex, cohort, and AD diagnosis were the independent variables. Kaplan-Meier plot to visualize the probability of (D) MCI participants at ADNI baseline free from converting to AD and (E) CN patients free from converting to MCI for low mtDNA-CN group and high mtDNA-CN group. mtDNA-CN was dichotomized by the median