Table 3 The effect of modifiable risk factors on progression to MCI and/or dementia

aHR (95% CI)

aHR (95% CI)

aHR (95% CI)

aHR (95% CI)

Higher CAIDE score

A-

1.6 (0.89; 2.93)

A + 

1.0 (0.49; 1.92)

A-

3.1 (1.43; 6.53)

A + 

1.3 (0.98; 1.75)

T-

1.1 (0.54; 2.40)

T + 

1.0 (0.55; 2.01)

T-

1.6 (0.94; 2.83)

T + 

1.7 (1.20; 2.27)

A-T-

1.9 (0.80; 4.25)

A + T + 

0.9 (0.39; 2.15)

A-T-

2.6 (1.06; 6.59)

A + T + 

1.6 (1.15; 2.22)

Smoking

A-

n.e.

A + 

n.e.

A-

1.3 (0.39; 4.23)

A + 

1.6 (1.07; 2.34)

T-

n.e.

T + 

n.e.

T-

1.8 (0.89; 3.78)

T + 

1.5 (0.99; 2.31)

A-T-

n.e.

A + T + 

n.e.

A-T-

n.e.

A + T + 

n.e.

Depression

A-

1.6 (0.81; 3.36)

A + 

1.0 (0.42; 2.60)

A-

1.0 (0.48; 2.19)

A + 

1.2 (0.86; 1.57)

T-

1.2 (0.44; 3.19)

T + 

1.1 (0.48; 2.45)

T-

0.6 (0.30; 1.05)

T + 

1.5 (1.06; 2.02)

A-T-

n.e.

A + T + 

n.e.

A-T-

0.6 (0.22; 1.49)

A + T + 

1.3 (0.94; 1.84)