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Table 2 Linear mixed-effect modelling for CSO-PVS and BG-PVS in cognitively unimpaired subjects. Models show different trajectories over time, effects of age, sex and years of education. Models with correlated slope and random intercept: PVS ~ age + age2 + time + sex + years of education + total intracranial volume + (1 + time | subject)

From: Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study

 

CSO-PVS

BG-PVS

 

B

SE

CI

p

B

SE

CI

p

(Intercept)

0.03

0.09

-0.14 – 0.20

0.733

0.09

0.09

-0.08 – 0.26

0.307

age (linear)

0.12

0.04

0.02 – 0.22

0.017

0.19

0.05

0.09 – 0.28

< 0.001

age (quadratic)

-0.13

0.04

-0.22 – -0.04

0.006

-0.09

0.05

-0.18 – -0.00

0.047

time

0.04

0.01

0.02 – 0.05

< 0.001

0.05

0.01

0.03 – 0.07

< 0.001

sex

0.18

0.08

-0.07 – 0.43

0.166

0.12

0.12

-0.25 – 0.24

0.959

years of education

-0.01

0.04

-0.11 – 0.08

0.830

-0.01

0.05

-0.10 – 0.08

0.831

sbTIV

0.23

0.06

0.10 – 0.35

 < 0.001

0.09

0.06

-0.03 – 0.21

0.150

σ2

0.09

0.18

τ00

0.74 Subject

0.69 Subject

τ11

0.01 Subject.time

0.00 Subject.time

ρ01

0.01Subject

-0.25Subject

ICC

0.89

0.79

N

383 Subject

387 Subject

Observations

1364

1381

Marginal R2 / Conditional R2

0.066 / 0.901

0.058 / 0.804

  1. Annotations. σ2 = residual variance; τ00 = random intercept variance; τ11 = random slope variance; ρ01 = covariance between random slope and intercept