Table 2 Linear mixed-effect modelling for CSO-PVS and BG-PVS in cognitively unimpaired subjects. Models show different trajectories over time, effects of age, sex and years of education. Models with correlated slope and random intercept: PVS ~ age + age2 + time + sex + years of education + total intracranial volume + (1 + time | subject)
CSO-PVS | BG-PVS | |||||||
|---|---|---|---|---|---|---|---|---|
B | SE | CI | p | B | SE | CI | p | |
(Intercept) | 0.03 | 0.09 | -0.14 – 0.20 | 0.733 | 0.09 | 0.09 | -0.08 – 0.26 | 0.307 |
age (linear) | 0.12 | 0.04 | 0.02 – 0.22 | 0.017 | 0.19 | 0.05 | 0.09 – 0.28 | < 0.001 |
age (quadratic) | -0.13 | 0.04 | -0.22 – -0.04 | 0.006 | -0.09 | 0.05 | -0.18 – -0.00 | 0.047 |
time | 0.04 | 0.01 | 0.02 – 0.05 | < 0.001 | 0.05 | 0.01 | 0.03 – 0.07 | < 0.001 |
sex | 0.18 | 0.08 | -0.07 – 0.43 | 0.166 | 0.12 | 0.12 | -0.25 – 0.24 | 0.959 |
years of education | -0.01 | 0.04 | -0.11 – 0.08 | 0.830 | -0.01 | 0.05 | -0.10 – 0.08 | 0.831 |
sbTIV | 0.23 | 0.06 | 0.10 – 0.35 | < 0.001 | 0.09 | 0.06 | -0.03 – 0.21 | 0.150 |
σ2 | 0.09 | 0.18 | ||||||
τ00 | 0.74 Subject | 0.69 Subject | ||||||
τ11 | 0.01 Subject.time | 0.00 Subject.time | ||||||
ρ01 | 0.01Subject | -0.25Subject | ||||||
ICC | 0.89 | 0.79 | ||||||
N | 383 Subject | 387 Subject | ||||||
Observations | 1364 | 1381 | ||||||
Marginal R2 / Conditional R2 | 0.066 / 0.901 | 0.058 / 0.804 | ||||||