Alzheimer's Research & Therapy

Table 2 Diagnosis utility of HTS and Neucop-Q on account of amyloid or tau PET positivity

From: Can the clinical sign “head-turning sign” and simple questions in “Neucop-Q” predict amyloid β pathology?

		Amyloid PET						Tau PET						non-AD Tau PET
		(+)	(-)					(+)	(-)					(+)	(-)
HTS	pos	20	3	0.870	PPV	HTS	pos	22	1	0.957	PPV	HTS	pos	2	1		0.667	PPV
HTS	neg	25	40	0.615	NPV	HTS	neg	48	17	0.262	NPV	HTS	neg	24	16		0.400	NPV
		0.444	0.930					0.314	0.944					0.077	0.941
		sens.	spec.					sens.	spec.					sens.	spec.
		Amyloid PET						Tau PET						non-AD Tau PET
		(+)	(-)					(+)	(-)					(+)	(-)
Consc.	imp	39	40	0.494	PPV	Consc.	imp	58	21	0.734	PPV	Consc.	imp	20	20		0.500	PPV
Consc.	nor	19	57	0.750	NPV	Consc.	nor	48	28	0.368	NPV	Consc.	nor	29	28		0.491	NPV
		0.672	0.588					0.547	0.571					0.408	0.583
		sens.	spec.					sens.	spec.					sens.	spec.
		Amyloid PET						Tau PET						non-AD Tau PET
		(+)	(-)					(+)	(-)					(+)	(-)
Pleas.	imp	11	21	0.344	PPV	Pleas.	imp	25	7	0.781	PPV	Pleas.	imp	14	7		0.667	PPV
Pleas.	nor	47	76	0.618	NPV	Pleas.	nor	81	42	0.341	NPV	Pleas.	nor	35	41		0.539	NPV
		0.190	0.784					0.236	0.857					0.286	0.854
		sens.	spec.					sens.	spec.					sens.	spec.
		Amyloid PET						Tau PET						non-AD Tau PET
		(+)	(-)					(+)	(-)					(+)	(-)
News	imp	30	23	0.566	PPV	News	imp	43	10	0.811	PPV	News	imp	13	10		0.565	PPV
News	nor	28	74	0.725	NPV	News	nor	63	39	0.382	NPV	News	nor	36	38		0.514	NPV
		0.517	0.763					0.406	0.796					0.265	0.792
		sens.	spec.					sens.	spec.					sens.	spec.

Cons.: consciousness, Pleas.: pleasure, imp: impaired, normal: nor, sens.: sensitivity, spec.: specificity, PET: positron emission tomography, PPV: positive predictive value, NPV: negative predictive value, HTS: head-turning sign

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