Fig. 4

Cross-domain intercept-slope and slope-slope associations.A Predicted four-year changes in cortical thickness and WMH trajectories, stratified by baseline WMH volumes and cortical thickness, respectively. We categorised individuals based on whether their latent intercepts were below the 25th or above the 75th percentile, respectively. B Relationship between predicted changes in cortical thickness and WMH volumes over four years. We back-transformed all predicted measurements to plotting for interpretability purposes. We adjusted latent intercepts and slopes for age, sex, years of education, total cardiovascular risk scores, and TICV