Frontotemporal structure preservation underlies the protective effect of lifetime intellectual cognitive reserve on cognition in the elderly

Table 4 The mediation model of LICR- gray matter volume-cognition

Model path	coefficient	SE	p	95% CI
Structural model: Direct effect
Fusiform_R → Episodic Memory (EM)	0.04	0.03	0.25	[-0.03, 0.09]
LICR → EM	0.15	0.03	< 0.001	[0.09, 0.20]
LICR → Fusiform_R	0.09	0.03	0.002	[0.03, 0.15]
Fusiform_R → Executive Processing Ability (EPA)	0.09	0.03	0.001	[0.04, 0.14]
LICR → EPA	0.37	0.03	< 0.001	[0.32, 0.42]
LICR → Fusiform_R	0.09	0.03	0.002	[0.03, 0.15]
Fusiform_R → Language Ability (LA)	0.07	0.03	0.015	[0.01, 0.13]
LICR → LA	0.22	0.03	< 0.001	[0.16, 0.27]
LICR → Fusiform_R	0.09	0.03	0.002	[0.03, 0.15]
Fusiform_R → General Cognitive Ability (GCA)	0.08	0.03	0.002	[0.03, 0.13]
LICR → GCA	0.32	0.03	< 0.001	[0.27, 0.37]
LICR → Fusiform_R	0.09	0.03	0.002	[0.03, 0.15]
Structural model: Indirect effect
LICR → Fusiform_R → EM	0.003	0.003	0.30	[-0.002, 0.01]
LICR → Fusiform_R → EPA	0.008	0.004	0.02	[0.003, 0.02]
LICR → Fusiform_R → LA	0.006	0.003	0.058	[0.001, 0.02]
LICR → Fusiform_R → GCA	0.008	0.003	0.03	[0.002, 0.02]
Structural model: Total effect
LICR → EM	0.15	0.03	< 0.001	[0.10, 0.22]
LICR → EPA	0.38	0.03	< 0.001	[0.33, 0.43]
LICR → LA	0.23	0.03	< 0.001	[0.17, 0.28]
LICR → GCA	0.33	0.03	< 0.001	[0.27, 0.37]

ISSN: 1758-9193