Table 4 Demographic and clinical characteristics for patients receiving a diagnosis (n = 556) or no diagnosis (n = 136) after stepwise cognitive testing, MRI, and CSF

True diagnosis, n (%)

0.003

 CN^a

22 (16)

166 (30)

 AD

58 (43)

244 (44)

 FTD^a

29 (21)

78 (14)

 VaD^a

9 (7)

26 (5)

 DLB

18 (13)

42 (8)

Demographics

 Age, years

66 ± 8

65 ± 9

0.044

 Sex, female

66 (48.5)

242 (43.5)

0.339

 Education, years

13 [10-16]

15 [12-17]

0.080

Neuropsychology

 MMSE [0–30]

25 [22-27]

25 [22-28]

0.078

 Memory, learning

26 ± 8

30 ± 12

0.002

 Memory, recall

4 ± 3

5 ± 4

0.015

 TMT-A (s)

73 ± 40

60 ± 36

 < 0.001

 TMT-B (s)

178 ± 91

145 ± 83

 < 0.001

 Animal fluency

14 ± 6

16 ± 8

0.029

Neuropsychiatric symptoms

 GDS [0–15]

4 ± 3

3 ± 2

0.001

 NPI, total score

15 ± 14

12 ± 12

0.011

Functional assessment

 DAD [0–100]

78.0 ± 22.8

84.3 ± 18.3

0.006

Automated MRI biomarkers

 cMTA, left

1.38 ± 1.12

1.24 ± 1.11

0.169

 cMTA, right

1.26 ± 1.01

1.17 ± 1.07

0.372

 cGCA

1.19 ± 0.77

1.09 ± 0.77

0.166

 cFazekas

1.14 ± 0.89

0.97 ± 0.85

0.032

 WMH, volume

10.47 ± 16.58

8.26 ± 15.22

0.137

 Anterior–posterior index

-0.33 ± 2.12

-0.09 ± 1.96

0.195

 AD similarity

0.53 ± 0.13

0.51 ± 0.15

0.048

Cerebrospinal fluid

 Aβ₄₂, pg/ml

824 ± 269

821 ± 293

0.925

 Total tau, pg/ml

439 ± 277

5056 ± 378

0.057

 p-tau, pg/ml

59 ± 29

65 ± 36

0.065