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Table 2 Multivariate regression analysis of CT measurements by diagnostic group

From: Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment: data from the NORFACE cohort

Covariates

Dependent variables

Coefficient

t

Significance

Beta

Diagnostic groups: CU vs MCI-AD

Center

16.44

2.13

0.034

0.07

In Temporal

20.05

2.81

0.005

0.09

In Superior

17.88

2.40

0.017

0.08

In Nasal

27.18

3.48

0.001*

0.12

In Inferior

20.75

2.83

0.005

0.09

Out Temporal

19.63

2.97

0.003*

0.10

Out Superior

18.18

2.70

0.007

0.09

Out Nasal

26.08

3.83

 < 0.001*

0.13

Out Inferior

22.39

3.40

0.001*

0.11

Average thickness

21.54

3.44

0.001*

0.11

Subfoveal choroidal thickness

15.75

1.96

0.051

0.07

Total volume

0.61

3.41

0.001*

0.11

Diagnostic groups: CU vs MCI-Va

Center

17.69

1.85

0.065

0.06

In Temporal

22.00

2.49

0.013

0.08

In Superior

21.57

2.34

0.020

0.08

In Nasal

24.92

2.57

0.010

0.08

In Inferior

21.02

2.31

0.021

0.07

Out Temporal

21.27

2.60

0.009

0.08

Out Superior

24.94

2.99

0.003*

0.09

Out Nasal

24.40

2.90

0.004*

0.09

Out Inferior

24.69

3.03

0.003*

0.10

Average thickness

23.52

3.03

0.002*

0.10

Subfoveal choroidal thickness

17.85

1.79

0.074

0.06

Total volume

0.66

3.00

0.003*

0.09

Diagnostic groups: CU vs ADD

Center

9.75

1.32

0.187

0.06

In Temporal

17.49

2.57

0.010

0.11

In Superior

10.33

1.45

0.147

0.06

In Nasal

15.32

2.05

0.040

0.09

In Inferior

14.54

2.08

0.038

0.09

Out Temporal

13.95

2.21

0.027

0.10

Out Superior

9.99

1.55

0.121

0.07

Out Nasal

15.60

2.40

0.016

0.11

Out Inferior

19.27

3.06

0.002*

0.13

Average thickness

14.54

2.43

0.015

0.10

Subfoveal choroidal thickness

9.92

1.29

0.197

0.06

Total volume

0.41

2.42

0.016

0.10

Diagnostic groups: CU vs VaD

Center

27.79

2.57

0.010

0.09

In Temporal

29.51

2.96

0.003*

0.10

In Superior

25.17

2.42

0.016

0.08

In Nasal

37.85

3.47

0.001*

0.12

In Inferior

35.20

3.43

0.001*

0.11

Out Temporal

27.74

3.01

0.003*

0.10

Out Superior

23.29

2.47

0.014

0.08

Out Nasal

37.17

3.91

 < 0.001*

0.13

Out Inferior

35.43

3.85

 < 0.001*

0.13

Average thickness

31.08

3.55

 < 0.001*

0.12

Subfoveal choroidal thickness

28.13

2.50

0.013

0.08

Total volume

0.88

3.55

 < 0.001*

0.12

  1. Multivariate regression analysis showing the contribution of diagnosis (CU, MCI-AD, MCI-Va, ADD, and VaD) to variance in CT measurements. The analysis included the following adjusting factors: age, sex, years of education, hypertension, diabetes mellitus, heart disease, COPD, stroke, smoking, and OCT image quality (data showed in Additional file 4). In bold, p < 0.05. (*) Significance was corrected with Bonferroni for multiple comparisons (p < 0.004)
  2. Abbreviations: ADD Alzheimer´s disease dementia, CT Choroidal thickness, CU Cognitively unimpaired, CV Cerebrovascular, MCI-AD Mild cognitive impairment due to Alzheimer´s disease, MCI-Va Mild cognitive impairment due to CV pathology, VaD Vascular dementia
  3. Regions in the ETDRS grid are divided into "Inner" and "Outer" zones, with "Inner" representing CT measurements within a 3 mm radius and "Outer" representing CT measurements within a 6 mm radius, corresponding to specific areas used for CT measurements in the study. The abbreviations used in the table are as follows: In Temporal = Inner Temporal, In Superior = Inner Superior, In Nasal = Inner Nasal, In Inferior = Inner Inferior. Similarly, Out Temporal = Outer Temporal, Out Superior = Outer Superior, Out Nasal = Outer Nasal, and Out Inferior = Outer Inferior
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Alzheimer's Research & Therapy

ISSN: 1758-9193