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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease

Fig. 2

legend: Associations between Vascular Score (VS), CSF t-tau levels and Qalb in patients with AD. Results on All AD are reported in gray, EOAD are displayed in pink, cLOAD in blue and vLOAD in green. All models are controlled for sex and APOE status. (A) Cross-sectional linear regressions between VS and CSF t-tau, (B) and between VS and Qalb, in All AD (gray) EOAD (pink), cLOAD (blue) and vLOAD (green). Colored areas represent 95% confidence interval. Standardized beta-estimates (β) and p-values were derived from linear regressions. (C) Cross-sectional mediation analyses with VS as predictor, Qalb as mediator, and CSF t-tau as the dependent variable in All AD, EOAD, cLOAD and vLOAD. Standardized Beta-estimates (β) and p-values for each path are displayed on the respective arrow. The average causal mediation effect (ACME) and the average direct effect (ADE) are reported under each mediation triangle

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Alzheimer's Research & Therapy

ISSN: 1758-9193