Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease

Table 2 Multivariable regression analysis showing the contribution of each vascular risk factor to cumulative vascular score in each cohort of patients

	All AD	EOAD	cLOAD	vLOAD
	β	β	β	β
Hypertension	0.440***	0.493***	0.427***	0.391***
Atrial Fibrillation	0.123***	n.a.	0.076***	0.214***
Smoke	0.343***	0.462***	0.301***	0.300***
DM type 2	0.340***	0.346***	0.337***	0.339***
Stroke or TIA	0.172***	n.a.***	0.197***	0.190***
Myocardial Infarction	0.215***	0.164***	0.232***	0.216***
OSAS	0.145***	0.164***	0.168***	n.a.
Dyslipidemia	0.440***	0.501***	0.428***	0.414***

Legend. EOAD: early-onset AD (< 65 yo); cLOAD: classical onset AD (65–75 yo); vLOAD: late-onset AD (> 75 yo); DM: Diabetes Mellitus; TIA: Transient Ischemic Attack; OSAS: Obstructive Sleep Apnea Syndrome; n.a.: not applicable; ***= pvalue < 0.001; Bold values represent β > 0.29 (moderate effect size)

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