Age of onset moderates the effects of Vascular Risk Factors on Neurodegeneration, Blood-Brain-Barrier permeability, and cognitive decline in Alzheimer’s Disease

Table 3 Cross-sectional multivariable regressions adjusted for sex and APOE genotype

	All AD		EOAD		cLOAD		vLOAD
	β	p	β	p	β	P	β	p
CSF *p-tau/Aβ42*
Vascular Score	0.010	0.846	0.077	0.491	−0.038	0.607	0.040	0.687
Hypertension	−0.010	0.841	0.106	0.350	−0.048	0.523	−0.071	0.478
Smoke	−0.065	0.248	−0.077	0.493	−0.137	0.090	0.169	0.152
DM type 2	0.0012	0.969	0.001	0.996	0.004	0.960	−0.026	0.794
Dyslipidemia	0.018	0.758	0.164	0.180	−0.050	0.535	0.025	0.835
CSF t-tau
Vascular Score	0.152	0.003**	0.256	0.019*	0.007	0.925	0.339	< 0.001***
Hypertension	0.086	0.098	0.227	0.041*	0.002	0.980	0.082	0.428
Smoke	−0.005	0.925	−0.031	0.780	−0.148	0.063	0.352	0.002**
DM type 2	0.035	0.495	0.134	0.220	0.045	0.541	−0.059	0.564
Dyslipidemia	0.119	0.039*	0.253	0.034*	−0.070	0.381	0.332	0.005**
Qalb
Vascular Score	0.135	0.009**	0.128	0.244	0.186	0.013*	0.091	0.344
Hypertension	0.176	< 0.001***	0.195	0.081	0.224	0.003**	0.119	0.266
Smoke	−0.071	0.207	−0.148	0.178	−0.050	0.544	−0.041	0.714
DM type 2	0.107	0.038*	0.028	0.799	0.180	0.017*	0.057	0.588
Dyslipidemia	0.038	0.504	0.092	0.438	0.013	0.877	0.002	0.987

Legend. EOAD: early-onset AD (< 65 yo); cLOAD: classical onset AD (65–75 yo); vLOAD: late-onset AD (> 75 yo); CSF: Cerebrospinal fluid; Qalb: Cerebrospinal fluid/serum albumin quotient; DM: Diabetes Mellitus; p: p-value; *=p < 0.05; **=p < 0.01; ***=p < 0.011. Bold values represent statistical significativity. All values are adjusted for Sex and APOE genotype

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