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Fig. 11 | Alzheimer's Research & Therapy

Fig. 11

From: Unveiling the molecular mechanisms of Danggui-Shaoyao-San against Alzheimer’s disease in APP/PS1 mice via integrating proteomic and metabolomic approaches

Fig. 11

DSS regulated GSK3β/PGC1α signalling pathway. (A,B) The relative mRNA expression level of GSK3β and PGC1α in mouse cortex by qPCR analysis. (C-F) Protein expression of GSK3β, p-GSK3β and PGC1α in mouse cortex and hippocampus by western blot analysis. Data are presented as mean ± SEM, n = 3 mice per group. #p < 0.05, ##p < 0.01 vs. the control group. *p < 0.05, **p < 0.01 vs. the model group, ns, no significant difference. Con, control group; Mod, model group; LiC, inhibitor group; DON, positive control group; DH, high dose of DSS group; DM, medium dose of DSS; DL, low dose of DSS group. One-way ANOVA followed by LSD difference multiple comparison tests (A, B, D, and F)

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Alzheimer's Research & Therapy

ISSN: 1758-9193