Fig. 2

DSS improved cognitive function in APP/PS1 mice. (A) Schematic diagram of spontaneous alternation. (B) Alternation rates of all groups of mice in the Y-maze test. (C) Representative track images of mice in the Y-maze test. (D) Representative track images of mice in the Morris water maze (MWM) test. (E) Escape latency during training days in the MWM test. (F) Numbers of target crossings in the MWM test. (G) Time stayed in the target quadrant in the MWM test. (H) Escape latency of all groups of mice in the MWM test. Data are shown as mean ± SEM, n = 10 mice per group. ^##p < 0.01 vs. the control group. *p < 0.05, **p < 0.01 vs. the model group, ns, no significant difference. Con, control group; Mod, model group; LiC, inhibitor group; Don, positive control group; DH, high dose of DSS group; DM, medium dose of DSS group; DL, low dose of DSS group. One-way ANOVA, followed by LSD method multiple comparisons tests (B, E, G, and H) or non-parametric independent samples Kruskal–Wallis test (F)