Fig. 2

Representative [18F]PI-2620 and [18F]RO948 PET images of study participants. Figure shows the SUVR maps superimposed to the MRI images of representative participants obtained with [18F]PI-2620 (left) and [18F]RO948 (right). The first 4 rows represent participants with visible tau PET deposition. The last three rows show examples of off-target signals. The off-target signals are indicated by the colored arrow with the following meaning: dark blue: substantia nigra; purple: nasal mucosa; red: superior cerebellar cortex; black: calcification; white: skull/meninges; light green: cavernous sinus/base of the skull; dark green: venous sinus; pink: scalp; light blue: eyes/retina; yellow: choroid plexus; orange: pineal gland