Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort

Table 2 Quantitative results from [¹⁸F]RO948 and [¹⁸F]PI-2620 SUVR in Braak regions

ROI	[¹⁸F]RO948 SUVR	[¹⁸F]PI-2620 SUVR	SUVR difference	R²[95% CI]	Slope [95% CI]	Intercept [95% CI]
Braak I	1.34 ± 0.26	1.42 ± 0.24	−0.079 ± 0.143	0.69 [0.47; 0.83]	0.90 [0.64; 1.48]	0.21 [−0.50; 0.55]
Braak II	1.01 ± 0.18	1.00 ± 0.18	0.004 ± 0.104	0.70 [0.48; 0.83]	1.00 [0.69; 1.42]	−0.01 [−0.39; 0.30]
Braak III	1.15 ± 0.20	1.09 ± 0.20	0.062 ± 0.093	0.80 [0.51; 0.87]	1.04 [0.70; 1.40]	−0.11 [−0.51; 0.27]
Braak IV	1.27 ± 0.21	1.15 ± 0.23	0.120 ± 0.104	0.79 [0.18; 0.88]	1.11 [0.65; 1.60]	−0.26 [−0.88; 0.29]
Braak V	1.06 ± 0.15	0.94 ± 0.18	0.126 ± 0.103	0.67 [0.01; 0.78]	1.22 [0.70; 2.03]	−0.36 [−1.23; 0.18]
Braak VI	1.01 ± 0.13	0.88 ± 0.15	0.126 ± 0.091	0.65 [0.20; 0.77]	1.19 [0.69; 2.07]	−0.32 [−1.22; 0.17]

Pearson R square, slope, and intercept are tabulated for every Braak region. Slope and intercept were calculated using a total least square approach, with [18F]RO948 as independent variable (i.e., SUVR_PI2620 = slope * SUVR_RO948 + intercept). Abbreviations: CI confidence interval, ROI region of interest, SUVR standardized uptake value ratio

ISSN: 1758-9193