Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort

Table 3 Off-target [¹⁸F]PI-2620 and [¹⁸F]RO948 SUVR measurements

ROI	[¹⁸F]RO948 SUVR	[¹⁸F]PI-2620 SUVR	SUVR difference	R²[95% CI]	Slope [95% CI]	Intercept [95% CI]
Thalamus	0.75 ± 0.12	0.73 ± 0.14	0.02 ± 0.12	0.29 [0.03; 0.64]	1.32 [0.55; 4.03]	−0.26 [−2.29; 0.29]
Striatum	0.88 ± 0.16	0.75 ± 0.15	0.13 ± 0.12	0.51 [0.19;0.75]	0.90 [0.60; 1.69]	−0.04 [−0.69;0.22]
White Matter	1.08 ± 0.17	0.94 ± 0.18	0.14 ± 0.12	0.61 [0.15; 0.81]	1.05 [0.66; 2.12]	−0.19 [−1.34; 0.21]
Choroid Plexus	0.86 ± 0.15	1.00 ± 0.27	−0.14 ± 0.19	0.54 [0.06; 0.89]	2.11 [1.32; 8.69]	−0.82 [−6.05;−0.18]
Skull/meninges	1.05 ± 0.27	0.92 ± 0.21	0.13 ± 0.15	0.67 [0.36; 0.90]	0.74 [0.46; 1.00]	0.14 [−0.09; 0.43]

Pearson R square, slope, and intercept are tabulated for every off-target region considered. Slope and intercept were calculated using a total least square approach, with [18F]RO948 as independent variable (i.e., SUVR_PI2620 = slope * SUVR_RO948 + intercept). Abbreviations: CI confidence interval, ROI region of interest, SUVR standardized uptake value ratio

ISSN: 1758-9193