Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway

Table 5 IDO2 methylation association with age and cognitive test in the BBACL cohort

		β	S.E.	t	p-value	95% CI
Baseline	Age
	Model 1^a	−0.110	0.040	−2.750	0.006	−0.189	−0.031
	Model 2	−0.126	0.049	−2.558	0.011	−0.223	−0.029
	normMMSE
	Model 1	−0.012	0.023	−0.519	0.604	−0.058	0.034
	Model 2	−0.042	0.029	−1.464	0.145	−0.099	0.015
Converter	Age
	Model 1^a	−0.139	0.053	−2.630	0.009	−0.244	−0.035
	Model 2	−0.163	0.067	−2.446	0.016	−0.296	−0.031
	normMMSE
	Model 1	0.007	0.028	0.242	0.809	−0.048	0.061
	Model 2	−0.037	0.035	−1.042	0.300	−0.107	0.033

Association between IDO2 percent methylation at position cg11251498 with age or normalized MMSE (normMMSE) for baseline diagnosis and in view of conversion within 76 months. Model 1 adjusted for age, gender, education and diagnosis/converters, while model 2 adjusted for model 1 + lifestyle factors (tobacco use, alcohol use, and body mass index (BMI))
Abbreviations: normMMSE normalized mini mental state exam, β beta value, S.E. standard error, t t statistic, 95% CI 95% confidence interval
^aModel 1 for age association adjusted for gender, education, and diagnosis/converters.

ISSN: 1758-9193