Table 3 Associations between optical coherence tomography measurements at baseline and risk of cognitive decline

Participants who developed cognitive decline, n = 280 (57%)

Macular GCIPL, μm

Superior sector

1.21 (1.09–1.34)

< 0.001

1.17 (1.04–1.31)

0.007

Superior nasal sector

1.21 (1.08–1.36)

0.001

1.18 (1.04–1.34)

0.008

Superior temporal sector

1.18 (1.05–1.32)

0.006

1.12 (0.99–1.26)

0.074

Inferior sector

1.13 (1.01–1.27)

0.040

1.09 (0.96–1.23)

0.192

Inferior nasal sector

1.21 (1.07–1.37)

0.002

1.17 (1.02–1.33)

0.021

Inferior temporal sector

1.10 (0.96–1.25)

0.175

1.04 (0.90–1.19)

0.618

Global

1.20 (1.07–1.35)

0.002

1.14 (1.01–1.30)

0.035

Macular RNFL, μm

Superior sector

0.97 (0.86–1.09)

0.617

0.94 (0.84–1.06)

0.341

Superior nasal sector

0.99 (0.88–1.12)

0.922

0.97 (0.86–1.10)

0.669

Superior temporal sector

0.97 (0.87–1.09)

0.598

0.96 (0.85–1.08)

0.464

Inferior sector

0.95 (0.84–1.08)

0.448

0.92 (0.81–1.03)

0.151

Inferior nasal sector

0.98 (0.85–1.12)

0.750

0.95 (0.82–1.09)

0.464

Inferior temporal sector

1.03 (0.88–1.21)

0.732

1.01 (0.87–1.19)

0.859

Global

0.98 (0.86–1.11)

0.714

0.95 (0.83–1.08)

0.432

Participants who developed cognitive decline,n = 204 (53%)

Peripapillary RNFL, μm

Temporal quadrant

1.12 (0.98–1.28)

0.092

1.10 (0.96–1.26)

0.187

Superior quadrant

0.99 (0.86–1.14)

0.902

0.95 (0.81–1.10)

0.477

Nasal quadrant

1.03 (0.89–1.18)

0.705

1.01 (0.87–1.16)

0.910

Inferior quadrant

1.11 (0.96–1.28)

0.174

1.03 (0.88–1.21)

0.694

Global

1.09 (0.95–1.25)

0.240

1.03 (0.88–1.20)

0.734