Table 4 Associations between optical coherence tomography measurements at baseline and risk of cognitive decline (in CIND and NCI only)

Participants who developed cognitive decline, n = 146 (45%)

Macular GCIPL, μm

Superior sector

1.33 (1.15–1.53)

< 0.001

1.28 (1.09–1.51)

0.003

Superior nasal sector

1.30 (1.12–1.51)

0.001

1.26 (1.06–1.49)

0.009

Superior temporal sector

1.25 (1.06–1.47)

0.008

1.15 (0.96–1.30)

0.143

Inferior sector

1.13 (0.97–1.33)

0.115

1.08(0.90–1.29)

0.430

Inferior nasal sector

1.26 (1.04–1.51)

0.016

1.23 (1.00-1.51)

0.045

Inferior temporal sector

1.13 (0.94–1.34)

0.193

1.02 (0.84–1.25)

0.838

Global

1.26 (1.08–1.48)

0.004

1.19 (0.99–1.44)

0.063

Macular RNFL, μm

Superior sector

1.07 (0.89–1.29)

0.457

1.03 (0.84–1.26)

0.751

Superior nasal sector

1.03 (0.86–1.23)

0.744

1.01 (0.84–1.21)

0.945

Superior temporal sector

1.03 (0.87–1.22)

0.754

1.03 (0.85–1.25)

0.769

Inferior sector

0.92 (0.79–1.08)

0.305

0.90 (0.76–1.08)

0.254

Inferior nasal sector

0.98 (0.83–1.17)

0.836

0.97 (0.80–1.17)

0.743

Inferior temporal sector

1.00 (0.81–1.23)

0.981

0.98 (0.77–1.23)

0.832

Global

1.00 (0.84–1.18)

0.998

0.98 (0.81–1.19)

0.844

Participants who developed cognitive decline,n = 107 (41%)

Peripapillary RNFL, μm

Temporal quadrant

1.11 (0.92–1.35)

0.272

1.06 (0.88–1.29)

0.527

Superior quadrant

1.02 (0.84–1.25)

0.821

0.95 (0.77–1.17)

0.628

Nasal quadrant

1.11 (0.92–1.35)

0.288

1.08 (0.88–1.30)

0.454

Inferior quadrant

1.14 (0.94–1.37)

0.187

1.06 (0.86–1.30)

0.561

Global

1.14 (0.94–1.38)

0.196

1.05 (0.86–1.28)

0.658