Fig. 3

Multi-planar views showing the voxel-wise results comparing the A/T/N positivity threshold approach and clustering approach. Voxel-wise results are shown with a cluster-size threshold of 275 voxels with p uncorrected < .005 on the left side and with the T-maps throughout the right side of the figure. CSF Aβ_42/40 positivity was considered when Aβ_42/40 < 0.071. CSF p-tau₁₈₁ positivity was considered when p-tau₁₈₁ > 24 pg/mL. C1 = AD-like co-expression, C2 = Neuroinflammation, and C3 = Synaptic cluster. R: Right, L: Left