Fig. 2

Combined contribution of the studied neuropathologies to grey matter loss. (A) Voxel-based morphometry results as a function of all neuropathologies, surviving whole-brain FWE correction for multiple comparisons. Results are thresholded at p < 0.05 and overlayed on an in-house template built from scans of elderly subjects. MNI coronal coordinates are provided, as well as left and right-side labels. Colormap indicates FWE-corrected p values. (B) Contrast estimates (effect sizes) for each variable, showing their effect on grey matter density in the region displaying significant effects (predicted density=∑(Contrast estimate)*(Pathology stage) through the five pathologies). Blue bars indicate 90% confidence interval. ADNC = Alzheimer’s Disease Neuropathological Change; FWE = family-wise error; HS = hippocampal sclerosis of aging; L = left; LATE = Limbic Predominant Age-Related TDP-43 Encephalopathy; LB = Lewy body pathology; MNI = Montreal Neurological Institute; R = right