Table 1 Demographics of the study participants
Demographics (n = 129) | Mean (SD) |
Age, years | 68.84 (3.69) |
Female Sex, No. (%) | 78 (60.47) |
Education, years | 13.15 (3.14) |
Body Mass Index, kg/m2 | 26.20 (4.31) |
APOE4 carriers, No. (%) | 35 (27.13) |
Short telomeres (< 3 kb), % | 9.86 (3.07) |
Global neuroimaging outcomes (n = 127) | |
Global GM volume, mm3 | 546,614.414 (25,805.89) |
Global glucose metabolism, SUVr (n = 88) | 1.11 (0.06) |
Neocortical Amyloid load, SUVr | 1.24 (0.15) |
WM kurtosis fractional anisotropy | 0.35 (0.02) |
WM mean kurtosis | 0.96 (0.04) |
Hippocampal subfields normalized volumes (n = 125) | |
CA1 | 0.95 (0.11) |
CA2 | 0.02 (0.003) |
CA3 | 0.05 (0.01) |
Dentate gyrus | 0.41 (0.06) |
Subiculum | 0.32 (0.04) |
Blood-based markers (n = 122) | |
NfL (pg/mL) | 20.18 (7.66) |
GFAP (pg/mL) | 155.54 (60.96) |
p-Tau181 (pg/mL) | 1.95 (0.79) |
Ratio Aβ42/40 | 0.07 (0.03) |
Aβ42 (pg/mL) | 10.36 (4.29) |
Aβ40 (pg/mL) | 156.40 (39.71) |