Association of critically short telomeres with brain and blood markers of ageing and Alzheimer’s disease in older adults

Table 2 Association of %CST with global neuroimaging outcomes

	%CST (z-scored)
	N	Standardized β coefficient	95% CI	P-value
Global GM volume^a	127	-.014	[-3856.3; 3856.3]	.858
Global Glucose metabolism^a	88	-.088	[-.103;-.074]	.427
Neocortical Amyloid load^b	127	-.173	[-.200;-.145]	.060
WM kurtosis fractional anisotropy^c	127	-.230	[-.234;-.226]	.010**
WM mean kurtosis^c	127	-.080	[-.088; -.073]	.371

^*P < 0.05. **P < 0.01. ***P < 0.001. The results are presented from linear regression after adjusting for age, sex, education and BMI. Bonferroni correction for multiple testing (p = 0.05/5 for the five global neuroimaging outcomes) is indicated in bold. Abbreviations: %CST Percentage of critically short telomeres, GM Gray matter, WM White matter, BMI Body mass index, CI Confidence interval

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