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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Greater baseline cortical atrophy in the dorsal attention network predicts faster clinical decline in Posterior Cortical Atrophy

Fig. 3

Baseline cortical atrophy predicts longitudinal clinical decline in PCA. (A) Colored vertices on the cortical surface indicate areas where greater atrophy (i.e., decreased thickness) at baseline predicted faster clinical decline as measured by change in CDR-SB scores in our PCA patients (n = 34). Vertex-wise values represent the difference in the estimated rates of change in CDR-SB scores (ΔSlope) between one standard deviation (SD) above and below the mean of baseline cortical thickness in the population. Statistical significance was assessed using a vertex-wise threshold corrected for multiple comparisons by controlling for the FDR at p < .05. (B) Line plots show predicted cortical thickness at each timepoint for each of the seven canonical cortical functional networks, separately for levels of baseline cortical thickness at one SD above and below the mean. Shaded bands denote 95% confidence intervals. VIS = visual; DA = dorsal attention; FP = frontoparietal; DM = default mode; VA = ventral attention; LIM = limbic; SOM = somatomotor. **p < .005

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Alzheimer's Research & Therapy

ISSN: 1758-9193