Fig. 4

Network-based characterization of baseline cortical atrophy and its utility for predicting clinical decline in PCA. (A) This map illustrates the boundaries of the seven canonical networks [30] on two flat maps representing the two cerebral cortical hemispheres; see Fig. 2B for the conventional cortical surface representation of these networks. The maps in (B) and (C) show unthresholded vertex-wise maps of effect size estimates. The first is a Cohen’s d map representing the magnitude of difference in baseline cortical thickness between PCA patients and Aβ- CU participants (B). The second is a ΔSlope map representing the difference in the rates of longitudinal change in CDR-SB scores between greater and lesser baseline atrophy relative to the mean (C). A joy plot (ridgeline plot) in each panel in (B) and (C) represents the distribution of vertex-wise effect size values within the DAN (green) and visual network (purple), revealing the more prominent involvement of visual network atrophy at baseline compared with the more prominent involvement of DAN atrophy in the prediction of longitudinal clinical decline. A more rightward distribution indicates overall larger effect sizes