Table 1 Clinical characteristics of the participant groups

Gender

47 M/26 F

71 M/74 F

45 M/58F

<0.001^χ2

<0.001

<0.001

<0.001

Age (y)

67(61 ~ 70.5)

63(58 ~ 67)

58(51 ~ 63)

<0.001^a

0.004

<0.001

<0.01

Education (y)

12(9 ~ 14)

12(9 ~ 15)

14(9 ~ 16)

0.002^a

0.07

0.001

0.302

BMI(kg/m ² )

25.01 ± 2.70

24.79 ± 3.00

24.36 ± 3.87

0.395^b

Alcohol, n(%)

34(46.6)

41(28.3)

26(25.2)

0.006^χ2

0.007

0.003

0.596

Smoke, n (%)

26(35.6)

33(22.8)

24(23.3)

0.095^χ2

Hypertension, n (%)

56(76.7)

70(48.3)

33(32.0)

<0.001^χ2

<0.001

<0.001

0.011

Diabetes, n(%)

37(50.7)

65(44.8)

30(29.1)

0.008^χ2

0.413

0.004

0.012

Hyperlipidemia, n(%)

42(57.5)

62(42.8)

36(35.0)

0.011^χ2

0.039

0.003

0.215

MoCA

23.90 ± 3.16

24.95 ± 3.70

25.98 ± 3.61

0.001^b

0.044

<0.001

0.026

SCWT

173.63 ± 55.66

146.79 ± 43.94

143.79 ± 111.96

0.023^b

0.015

0.011

0.757

Lacune

35(47.9%)

3(17.2%)

0(0%)

<0.001^χ2

<0.001

<0.001

<0.001

WMH

71(97.3%)

137(94.5%)

1(1%)

<0.001^χ2

0.355

<0.001

<0.001

PVS

63(86.3%)

50(34.5%)

1(1%)

<0.001^χ2

<0.001

<0.001

<0.001

CMBs

45(61.6%)

18(12.4%)

0(0%)

<0.001^χ2

<0.001

<0.001

<0.001

CSVD-Total score

 0

0

64

103

 1

0

81

0

 2

36

0

0

 3

21

0

0

 4

16

0

0