Brain iron deposition and cognitive decline in patients with cerebral small vessel disease : a quantitative susceptibility mapping study

Table 4 Mediation analysis results

	Estimated effect	95% Confidence interval		P
Paths	Estimated effect	lower	upper	P
Indirect effect
Age →CSVD total scores	0.233	0.0928	0.373	0.001
CSVD total scores → Striatum	0.137	0.005	0.269	0.041
Direct effect
Age → CSVD total scores → Striatum	0.337	0.197	0.477	<0.001

Independent variable: Age; Dependent variable: The mean susceptibility values of the striatum; Mediator: CSVD-total score; Covariates: sex and education levels

ISSN: 1758-9193