Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry

Table 2 Time interactions of ECog scores on longitudinal PAL scores in linear mixed effect model (n = 16,683)

Variable	PAL FAMS			PAL TEA score
Variable	Estimate (SE)	p value	R²m	Estimate (SE)	p value	R²m
Model 1
Self-ECog positive*Time (month)	-0.010 (0.003)	< 0.001*	0.562	0.046 (0.017)	0.005*	0.661
Self-ECog consistent*Time	-0.008 (0.003)	0.004*	0.562	0.038 (0.016)	0.020	0.660
Self-ECog total*Time	-0.006 (0.003)	0.062	0.562	0.026 (0.020)	0.185	0.661
SP-ECog positive*Time	-0.001 (0.007)	0.842	0.526	0.018 (0.041)	0.658	0.640
SP-ECog consistent*Time	-0.004 (0.007)	0.581	0.526	0.019 (0.039)	0.627	0.640
SP-ECog total*Time	-0.013 (0.008)	0.096	0.528	0.097 (0.048)	0.042	0.642
Model 2
Self-ECog positive*Time	-0.011 (0.003)	< 0.001*	0.559	0.046 (0.017)	0.006*	0.658
Self-ECog consistent*Time	-0.009 (0.003)	0.002*	0.559	0.039 (0.017)	0.020	0.658
Self-ECog total*Time	-0.006 (0.003)	0.073	0.559	0.024 (0.020)	0.235	0.658
SP-ECog positive*Time	-0.003 (0.007)	0.620	0.525	0.031 (0.042)	0.465	0.639
SP-ECog consistent*Time	-0.004 (0.007)	0.500	0.525	0.024 (0.040)	0.537	0.639
SP-ECog total*Time	-0.015 (0.008)	0.061	0.526	0.105 (0.049)	0.030	0.640

Each variable was separately put in a multivariable linear mixed effect model
Model 1: adjusted for baseline PAL score
Model 2: adjusted for age, gender, years of education, race, geriatric depression scale, family history of AD, AD medication use, self-reported any impairment, and baseline PAL score
*p values that survived false discovery rate correction using Benjamini-Hochberg method
ECog, Everyday cognition scale; PAL, paired associates learning; FAMS, first attempt memory score; TEA, total errors adjusted; SE, standard error; R²m, marginal R-squared; Self-ECog, self-reported ECog; SP-ECog, study partner-reported ECog; AD, Alzheimer’s disease

ISSN: 1758-9193