Table 3 League charts of observational studies. League charts of observational studies intercomparing the risks of Alzheimer’s disease among different anti-diabetic agents and placebo

1.07 (0.89,1.28)

Metformin

1.63 (0.95,2.80)

0.88 (0.71,1.08)

1.01 (0.87,1.16)

0.46 (0.31,0.68)

0.57 (0.32,1.04)

0.78 (0.59,1.02)

0.76 (0.19,3.09)

0.65 (0.39,1.09)

0.61 (0.36,1.05)

Insulin

0.54 (0.31,0.93)

0.62 (0.36,1.05)

0.28 (0.15,0.53)

0.35 (0.16,0.76)

0.48 (0.27,0.84)

0.46 (0.11,2.04)

1.22 (0.99,1.50)

1.14 (0.92,1.41)

1.86 (1.07,3.22)

TZD

1.15 (0.91,1.44)

0.52 (0.34,0.79)

0.65 (0.36,1.20)

0.88 (0.65,1.20)

0.86 (0.21,3.53)

1.06 (0.89,1.26)

0.99 (0.86,1.15)

1.62 (0.95,2.77)

0.87 (0.69,1.10)

Sulfonylureas

0.46 (0.31,0.66)

0.57 (0.32,1.02)

0.77 (0.60,0.98)

0.75 (0.18,3.07)

2.33 (1.61,3.37)

2.18 (1.48,3.22)

3.56 (1.90,6.67)

1.91 (1.26,2.90)

2.19 (1.51,3.19)

SGLT-2i

1.25 (0.80,1.95)

1.69 (1.28,2.24)

1.65 (0.39,6.99)

1.86 (1.04,3.32)

1.74 (0.96,3.15)

2.85 (1.32,6.15)

1.53 (0.83,2.82)

1.75 (0.98,3.14)

0.80 (0.51,1.25)

GLP-1RA

1.35 (0.80,2.30)

1.32 (0.29,5.98)

1.37 (1.07,1.76)

1.29 (0.98,1.68)

2.10 (1.20,3.70)

1.13 (0.83,1.54)

1.30 (1.02,1.65)

0.59 (0.45,0.78)

0.74 (0.44,1.25)

DPP-4i

0.98 (0.24,4.02)

1.41 (0.35,5.67)

1.32 (0.32,5.38)

2.15 (0.49,9.49)

1.16 (0.28,4.74)

1.33 (0.33,5.41)

0.61 (0.14,2.56)

0.76 (0.17,3.42)

1.02 (0.25,4.22)

AGI