Blood-based biomarkers and plasma Aβ assays in the differential diagnosis of Alzheimer’s disease and behavioral-variant frontotemporal dementia

Table 2 Diagnostic accuracy of Aβ40, Aβ42, Aβ42/40 ratio across assays, NfL, GFAP, and p-tau181

AD vs. NNC	n	AUC	95% CI	Sensitivity	Specificity
Aβ40 Simoa	16/12	0.64	[ 0.41–0.86 ]	0.50	0.75
Aβ40 Shimadzu	18/12	0.56	[ 0.34–0.78 ]	0.72	0.42
Aβ40 Ulm	18/12	0.44	[ 0.21–0.67 ]	0.44	0.67
Aβ42 Simoa	16/12	0.68	[ 0.45–0.90 ]	0.75	0.58
Aβ42 Shimadzu	18/12	0.69	[ 0.49–0.88 ]	0.67	0.75
Aβ42 Ulm	18/12	0.82	[ 0.67–0.97 ]	0.67	0.83
Aβ42/40 Simoa	16/12	0.57	[ 0.33–0.80 ]	0.75	0.50
Aβ42/40 Shimadzu	18/12	0.65	[ 0.45–0.85 ]	0.56	0.75
Aβ42/40 Ulm	18/12	0.82	[ 0.67–0.97 ]	0.78	0.83
Aβ composite score Shimadzu	18/12	0.79	[ 0.63–0.95 ]	0.72	0.75
Plasma GFAP	18/12	0.85	[ 0.72–0.99 ]	0.72	0.83
Plasma NfL	18/12	0.79	[ 0.78–1.00 ]	0.72	0.75
Plasma pTau181	18/12	0.90	[ 0.78–1.00 ]	0.83	0.92

bvFTD vs. NNC	n	AUC	95% CI	Sensitivity	Specificity
Aβ40 Simoa	19/12	0.72	[ 0.54–0.91 ]	0.63	0.75
Aβ40 Shimadzu	20/12	0.59	[ 0.38–0.80 ]	0.65	0.58
Aβ40 Ulm	20/12	0.41	[ 0.20–0.63 ]	0.55	0.5
Aβ42 Simoa	19/12	0.60	[ 0.37–0.82 ]	0.53	0.75
Aβ42 Shimadzu	20/12	0.74	[ 0.56–0.93 ]	0.75	0.75
Aβ42 Ulm	20/12	0.77	[ 0.60–0.93 ]	0.65	0.83
Aβ42/40 Simoa	19/12	0.67	[ 0.47–0.87 ]	0.74	0.58
Aβ42/40 Shimadzu	20/12	0.39	[ 0.18–0.60 ]	0.5	0.58
Aβ42/40 Ulm	20/12	0.79	[ 0.63–0.95 ]	0.8	0.67
Aβ composite score Shimadzu	20/12	0.67	[ 0.48–0.86 ]	0.6	0.75
Plasma GFAP	20/12	0.48	[ 0.25–0.70 ]	0.65	0.5
Plasma NfL	20/12	0.88	[ 0.77–1.00 ]	0.75	0.83
Plasma pTau181	20/12	0.62	[ 0.41–0.83 ]	0.55	0.83

AD vs. bvFTD	n	AUC	95% CI	Sensitivity	Specificity
Aβ40 Simoa	16/19	0.61	[ 0.42–0.81 ]	0.62	0.58
Aβ40 Shimadzu	18/20	0.51	[ 0.31–0.70 ]	0.56	0.65
Aβ40 Ulm	18/20	0.55	[ 0.36–0.74 ]	0.44	0.75
Aβ42 Simoa	16/19	0.56	[ 0.37–0.76 ]	0.75	0.42
Aβ42 Shimadzu	18/20	0.50	[ 0.31–0.69 ]	0.56	0.60
Aβ42 Ulm	18/20	0.52	[ 0.33–0.71 ]	0.61	0.50
Aβ42/40 Simoa	16/19	0.76	[ 0.58–0.93 ]	0.88	0.74
Aβ42/40 Shimadzu	18/20	0.54	[ 0.35–0.73 ]	0.56	0.65
Aβ42/40 Ulm	18/20	0.44	[ 0.25–0.63 ]	0.50	0.55
Aβ composite score Shimadzu	18/20	0.62	[ 0.44–0.81 ]	0.61	0.70
Plasma GFAP	18/20	0.87	[ 0.76–0.98 ]	0.78	0.80
Plasma NfL	18/20	0.62	[ 0.44–0.81 ]	0.83	0.55
Plasma pTau181	18/20	0.90	[ 0.79–1.00 ]	0.89	0.90

ISSN: 1758-9193