Fig. 7

Protective effects of FENM on neuroinflammation in the hippocampus of APP/PS1 mice. Vehicle solution (Veh) or FENM (0.1 mg/kg/day) was infused for 4 weeks SC or FENM (0.3 mg/kg) was injected IP o.d. for 4 weeks. animals were sacrificed 48 h after the last administration day. Levels of the cytokines TNFα (a) or IL-6 (b) and the glial markers GFAP (c) or Iba-1 (d) were analyzed in homogenates by ELISA. Data were expressed as percentage of the control, Veh-treated WT group. The number of animal per group was n = 5–6. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. the Veh-treated WT group; # p < 0.05, ## p < 0.01 vs. the Veh-treated APP/PS1 group; Dunnett's test