Fig. 8
Protective effects of FENM on neuroinflammation in the cortex of APP/PS1 mice. Vehicle solution (Veh) or FENM (0.1 mg/kg/day) was infused for 4 weeks SC or FENM (0.3 mg/kg) was injected IP o.d. for 4 weeks. animals were sacrificed 48 h after the last administration day. Levels of the pro-apoptotic marker Bax (a), the anti-apoptotic marker Bcl-2 (b), and the soluble (c, e) and insoluble (d, f) contents in Aβ1-40 (c, d) and Aβ1-42 (e, f) were analyzed in homogenates by ELISA. Correlations between Aβ1-40 and Aβ1-42 levels are shown in (g) for soluble extracts and in (h) for insoluble extracts. Data in (a, b) were expressed as percentage of the control, Veh-treated WT group. Data in (c-f) were expressed as pg/mg of tissue and represented as box-and-whiskers showing the median and range. The number of animal per group was n = 4–6. * p < 0.05 vs. the Veh-treated WT group; ## p < 0.01 vs. the Veh-treated APP/PS1 group; Dunnett's test