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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Therapeutic implications of necroptosis activation in Alzheimer´s disease

Fig. 1

Necroptosis activation in AD. Protein misfolding and accumulation leads to activation of the TNF signaling pathway. TNFR1 activation results in the recruitment of RIPK1. In the absence of caspase-8 activity, RIPK1 interacts with RIPK3 to form the necrosome. MLKL is recruited to the complex and phosphorylated by pRIPK3, which triggers its oligomerization and translocation to the plasma membrane, where executes necroptosis

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Alzheimer's Research & Therapy

ISSN: 1758-9193