Table 2 Generalized mixed regression models. First set of models are adjusted for sex, age, education (fixed effects) and site of recruitment (random effect); second set of models also adjusted for APOE-ε4 allele presence

AD ~ SEX + AGE + EDUCATION + ptau217 + (1|SITE)

HC vs. AD

0.75

0.45 1.05

1.31-E06

MCI vs. AD

0.59

0.32 0.87

1.97-E05

HC vs. MCI

-0.09

-0.38 0.20

0.53

AD ~ SEX + AGE + EDUCATION + APOE-ε4 + ptau217 + (1|SITE)

HC vs. AD

0.62

0.32 0.93

6.26-E05

MCI vs. AD

0.50

0.21 0.79

5.96-E04

HC vs. MCI

-0.13

-0.43 0.17

0.39