Table 3 APOE Genotype at baseline by sex
Male | Female | p-value (Fisher) | p-value (adjusted†) | |
|---|---|---|---|---|
All individuals | n = 1,163 | n = 2,875 | ||
APOE genotype | 0.34 | 0.63 | ||
APOE e4- | 675 (58.0%) | 1,760 (61.2%) | ||
e2e2 | 1 (0.1%) | 8 (0.3%) | ||
e2e3 | 56 (4.8%) | 165 (5.7%) | ||
e3e3 | 618 (53.1%) | 1,587 (55.2%) | ||
APOE e4+ | 488 (42.0%) | 1,115 (38.8%) | 0.07 | 0.15 |
e2e4 | 15 (1.3%) | 42 (1.5%) | ||
e3e4 | 413 (35.5%) | 943 (32.8%) | ||
e4e4 | 60 (5.2%) | 130 (4.5%) | ||
Age ≤ 70 yrs | n = 131 | n = 269 | ||
APOE genotype | 0.23 | 0.09 | ||
APOE e4- | 63 (48.1%) | 127 (47.2%) | ||
e2e2 | - | - | ||
e2e3 | 7 (5.3%) | 5 (1.9%) | ||
e3e3 | 56 (42.7%) | 122 (45.4%) | ||
APOE e4+ | 68 (51.9%) | 142 (52.8%) | 0.92 | 0.18 |
e2e4 | 3 (2.3%) | 4 (1.5%) | ||
e3e4 | 47 (35.9%) | 110 (40.9%) | ||
e4e4 | 18 (13.7%) | 28 (10.4%) | ||
Age > 70 yrs | n = 1,032 | n = 2,606 | ||
APOE genotype | 0.21 | 0.54 | ||
APOE e4- | 612 (59.3%) | 1,633 (62.7%) | ||
e2e2 | 1 (0.1%) | 8 (0.3%) | ||
e2e3 | 49 (4.7%) | 160 (6.1%) | ||
e3e3 | 562 (54.5%) | 1,465 (56.2%) | ||
APOE e4+ | 420 (40.7%) | 973 (37.3%) | 0.06 | 0.19 |
e2e4 | 12 (1.2%) | 38 (1.5%) | ||
e3e4 | 366 (35.5%) | 833 (32.0%) | ||
e4e4 | 42 (4.1%) | 102 (3.9%) |