Table 5 Changes in MMSE per year during follow-up
Sex | Patients (N) | Measures (M) | M/N | MMSE units/year (95%CI) | p-value | Sex interaction |
|---|---|---|---|---|---|---|
Males | 1719 | 6198 | 3.6 | -2.00 (-2.11,-1.90) | (ref) | - |
Females | 4335 | 17,105 | 3.9 | -2.06 (-2.12,-2.00) | 0.40 | |
Age at baseline | ||||||
<60 yrs | 90 | 333 | 3.7 | -3.68 (-4.11,-3.25) | (ref) | 0.64 |
60–69 yrs | 318 | 1338 | 4.2 | -2.88 (-3.10,-2.67) | < 0.01 | |
70–79 yrs | 1691 | 7560 | 4.5 | -2.06 (-2.15,-1.97) | < 0.01 | |
80–84 yrs | 1911 | 7530 | 3.9 | -1.92 (-2.00,-1.83) | < 0.01 | |
85 + yrs | 2044 | 6542 | 3.2 | -1.92 (-2.02,-1.82) | < 0.01 | |
Education | ||||||
No formal education | 1199 | 4695 | 3.9 | -1.77 (-1.88,-1.65) | (ref) | 0.42 |
Primary School | 3717 | 14,567 | 3.9 | -2.03 (-2.10,-1.97) | < 0.01 | |
Secondary School | 569 | 2148 | 3.8 | -2.32 (-2.49,-2.15) | < 0.01 | |
University | 409 | 1504 | 3.7 | -2.66 (-2.86,-2.46) | < 0.01 | |
Unknown | 160 | 389 | 2.4 | -1.95 (-2.81,-1.09) | 0.68 | |
Marital status | ||||||
Married/Partnered | 2940 | 11,854 | 4.0 | -2.08 (-2.20,-1.96) | (ref) | 0.54 |
Widowed | 2489 | 9356 | 3.8 | -2.01 (-2.14,-1.88) | 0.53 | |
Divorced/Separate | 166 | 592 | 3.6 | -1.71 (-2.04,-1.37) | 0.05 | |
Single | 311 | 1141 | 3.7 | -2.05 (-2.30,-1.81) | 0.87 | |
Unknown | 148 | 360 | 2.4 | -2.31 (-3.24,-1.38) | 0.64 | |
Cohabitation status | ||||||
Lives alone | 1411 | 5501 | 3.9 | -2.02 (-2.17,-1.88) | (ref) | 0.58 |
Lives with spouse/partner | 2539 | 10,315 | 4.1 | -2.01 (-2.14,-1.88) | 0.93 | |
Lives with someone (other) | 946 | 3469 | 3.7 | -2.16 (-2.33,-1.99) | 0.12 | |
Domestic group | 633 | 2458 | 3.9 | -1.99 (-2.15,-1.83) | 0.77 | |
Nursing home | 216 | 622 | 2.9 | -2.03 (-2.84,-1.22) | 0.98 | |
Unknown | 309 | 938 | 3.0 | -2.25 (-2.59,-1.91) | 0.19 | |
Caregiver | ||||||
None | 2226 | 9392 | 4.2 | -2.01 (-2.09,-1.92) | (ref) | 0.45 |
Spouse/Partner | 1032 | 4054 | 3.9 | -2.18 (-2.32,-2.04) | 0.03 | |
Son/Daughter | 624 | 2346 | 3.8 | -1.96 (-2.13,-1.79) | 0.64 | |
Professional | 624 | 1933 | 3.1 | -2.02 (-2.21,-1.84) | 0.87 | |
Residential Caregiver | 195 | 577 | 3.0 | -1.83 (-2.67,-0.99) | 0.70 | |
Other | 1353 | 5001 | 3.7 | -2.08 (-2.20,-1.97) | 0.27 | |
Arthrosis | ||||||
no | 2646 | 10,034 | 3.8 | -2.14 (-2.21,-2.06) | (ref) | 0.10 |
yes | 3245 | 12,710 | 3.9 | -1.99 (-2.06,-1.92) | 0.01 | |
unknown | 163 | 559 | 3.4 | -1.73 (-2.09,-1.38) | 0.03 | |
Depression | ||||||
no | 4069 | 15,495 | 3.8 | -2.11 (-2.17,-2.05) | (ref) | 0.12 |
yes | 1658 | 6604 | 4.0 | -1.87 (-1.97,-1.78) | < 0.01 | |
unknown | 327 | 1204 | 3.7 | -2.18 (-2.41,-1.94) | 0.59 |