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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease

Fig. 4

Transcription factor motif enrichment of chromatin accessibility reveals endotype-associated regulator differential activity. A TF motif enrichment of accessible ATAC-seq peaks (all peaks, promoter-associated peaks, and enhancer-associated peaks) using GimmeMotifs maelstrom with the SwissRegulon motif database. B chipenrich enrichment analysis of differentially accessible promoter-associated regions with increased accessibility (top) or decreased accessibility (bottom) using the GOBP and Hallmark ontology databases (Hallmark, H). C-D chipenrich enrichment analysis of differentially accessible enhancer-associated regions with differential accessibility using the (C) GOBP and Hallmark ontology databases or (D) ENCODE-ChEA Consensus and ReMap TF-gene target databases (ENCODE, E; ChEA, C; ReMap, R); FDR p-value < 0.05

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Alzheimer's Research & Therapy

ISSN: 1758-9193