Fig. 2

Correlation between baseline CSF β2M and CSF biomarkers using multivariate linear regression analyses. CSF β2M level was positive correlated with the Aβ₄₂ (A), P-tau (B) and T-tau (C), GFAP (D) and sTREM2 (E). There was no significant association between CSF and plasma β2M (F). Notes: The normalized regression coefficients (β) and P values computed by multiple linear regression after adjustment for age, gender, education, APOE ε4 status. Significant effects (P < 0.05) were shown in bold. Abbreviations: CSF, cerebrospinal fluid; β2M, β2-microglobulin; Aβ₄₂, amyloid-β1–42; P-tau, phosphorylated-tau; T-tau, total-tau; GFAP, glial fibrillary acidic protein; sTREM2, soluble triggering receptor expressed on myeloid cells 2; APOE, Apolipoprotein E