Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease

Fig. 5

Schematic interlinking of the effect of β2M based microglia-astrocyte communication on AD pathology. CSF β2M is mainly derived from activated microglia (also secretes sTREM2) and peripheral β2M across the blood–brain barrier. β2M may be involved in Aβ aggregation. Findings in the present study suggest that CSF β2M also upregulates the secretion of GFAP by reactive astrocytes to promote the increase of P-tau and T-tau. Abbreviations: Alzheimer's disease, AD; CSF, cerebrospinal fluid; β2M, β2-microglobulin; Aβ, amyloid-β; P-tau, phosphorylated-tau; T-tau, total-tau; GFAP, glial fibrillary acidic protein; sTREM2, soluble triggering receptor expressed on myeloid cells 2

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193