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Table 1 Association between the PCs with cognitive functions

From: Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis

 

Fluid intelligence

Pairs matching

Reaction time

Prospective memory

PC

OR (95%CI)

P

Pfdr

OR (95%CI)

P

Pfdr

OR (95%CI)

P

Pfdr

OR (95%CI)

P

Pfdr

1

0.96(0.95,0.98)

< 0.001

< 0.001

0.95(0.92,0.99)

0.018

0.133

0.98(0.96,0.99)

< 0.001

< 0.001

1.16(1.07,1.25)

0.010

0.072

2

1.01(1.00,1.01)

0.049

0.090

1.00(0.98,1.01)

0.838

0.934

1.00(1.00,1.01)

0.114

0.330

0.96(0.90,1.03)

0.137

0.441

3

0.99(0.99,1.00)

0.079

0.135

0.99(0.98,1.01)

0.396

0.574

1.00(0.99,1.00)

0.088

0.282

1.01(0.95,1.08)

0.472

0.757

4

1.00(0.99,1.01)

0.762

0.790

1.02(1.00,1.03)

0.054

0.224

1.00(0.99,1.00)

0.029

0.141

1.02(0.94,1.09)

0.134

0.441

5

1.08(1.06,1.09)

< 0.001

< 0.001

1.04(1.01,1.06)

0.009

0.084

1.00(0.99,1.00)

0.002

0.012

1.01(0.94,1.08)

< 0.001

< 0.001

6

1.03(1.03,1.04)

< 0.001

< 0.001

1.01(1.00,1.03)

0.129

0.314

1.00(0.99,1.00)

0.442

0.620

0.99(0.92,1.07)

0.403

0.749

7

1.02(1.01,1.02)

< 0.001

< 0.001

1.00(0.99,1.02)

0.976

0.982

1.00(1.00,1.00)

0.855

0.855

0.99(0.92,1.07)

0.938

0.939

8

1.00(0.99,1.01)

0.860

0.860

1.01(0.99,1.02)

0.430

0.593

1.00(1.00,1.01)

0.449

0.620

1.01(0.93,1.08)

0.299

0.620

9

1.00(0.99,1.01)

0.653

0.751

0.99(0.98,1.01)

0.227

0.412

1.00(1.00,1.00)

0.072

0.282

1.00(0.92,1.07)

0.851

0.939

10

1.01(1.00,1.01)

0.039

0.081

1.00(0.99,1.02)

0.784

0.920

1.01(1.00,1.02)

0.183

0.441

0.78(0.65,0.94)

0.939

0.939

11

1.00(0.99,1.01)

0.673

0.751

1.00(0.98,1.01)

0.793

0.920

1.01(1.00,1.01)

0.768

0.804

1.08(1.01,1.15)

0.526

0.763

12

1.01(1.00,1.02)

0.013

0.034

0.99(0.97,1.01)

0.190

0.366

1.00(1.00,1.01)

0.004

0.024

0.93(0.86,1.00)

0.826

0.939

13

1.00(0.99,1.00)

0.249

0.344

1.00(0.99,1.02)

0.764

0.920

1.00(0.99,1.00)

0.214

0.476

1.02(1.00,1.03)

0.847

0.939

14

0.99(0.99,1.00)

0.084

0.135

1.00(0.99,1.02)

0.925

0.982

1.00(1.00,1.01)

0.277

0.535

1.06(0.98,1.13)

0.038

0.183

15

0.98(0.97,0.99)

< 0.001

< 0.001

1.01(0.99,1.03)

0.181

0.366

1.00(1.00,1.01)

0.339

0.560

0.94(0.88,1.02)

0.295

0.620

16

1.01(1.01,1.02)

< 0.001

0.001

1.02(1.00,1.03)

0.040

0.195

1.00(1.00,1.01)

0.709

0.804

0.96(0.89,1.03)

0.030

0.174

17

1.00(1.00,1.01)

0.162

0.247

1.01(1.00,1.03)

0.087

0.291

1.00(0.99,1.00)

0.758

0.804

0.96(0.90,1.03)

0.649

0.896

18

0.98(0.97,0.99)

< 0.001

< 0.001

1.01(0.99,1.03)

0.180

0.366

1.00(0.99,1.00)

0.760

0.804

1.04(0.96,1.13)

0.918

0.939

19

0.99(0.98,1.00)

0.007

0.020

1.00(0.98,1.01)

0.619

0.816

1.00(1.00,1.01)

0.255

0.528

0.81(0.55,1.20)

0.887

0.939

20

1.05(1.04,1.06)

< 0.001

< 0.001

0.99(0.97,1.00)

0.130

0.314

1.00(0.99,1.00)

0.354

0.560

1.03(0.96,1.11)

< 0.001

0.002

21

1.00(0.99,1.00)

0.176

0.255

1.00(0.98,1.02)

0.982

0.982

0.99(0.97,1.01)

0.647

0.804

0.97(0.90,1.04)

0.486

0.757

22

1.01(1.00,1.01)

0.028

0.063

1.01(1.00,1.03)

0.118

0.314

1.00(1.00,1.01)

0.148

0.391

0.97(0.91,1.05)

0.683

0.900

23

1.00(0.99,1.00)

0.568

0.716

0.99(0.98,1.01)

0.307

0.495

1.00(0.99,1.00)

0.367

0.560

0.98(0.91,1.05)

0.262

0.620

24

1.00(0.99,1.01)

0.594

0.718

0.99(0.97,1.00)

0.090

0.291

1.00(0.99,1.00)

0.085

0.282

0.95(0.81,1.11)

0.413

0.749

25

0.99(0.99,1.00)

0.050

0.090

1.01(0.99,1.02)

0.358

0.546

1.00(1.00,1.01)

0.559

0.738

1.02(0.95,1.10)

0.231

0.620

  1. Note: multivariable linear and logistic analyses were conducted with adjustment of age, sex, APOE ε4, and all PCs. The Odds Ratio (OR) serves as an indicator of the correlation with cognitive function, with values exceeding 1 suggesting a positive risk association and values below 1 indicating a protective correlation
  2. Abbreviations: FI, Fluid intelligence; PAM, pairs matching; RT, reaction time; PM, prospective memory; PCs, principal component; Prdr, P value after FDR correction
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Alzheimer's Research & Therapy

ISSN: 1758-9193