Table 1 Summary of phenotypic scanning and reverse causality detection on the candidate causative gene ACE and alzheimer’s disease (Discovery)
Tissue | Gene | Source | TopSNP | P.smr | P.smr_multi | P.value_HEIDI | Steiger filter | Co.localization.PPH4 | Previously reported association |
|---|---|---|---|---|---|---|---|---|---|
Blood | ACE | eQTLGen | rs4277405 | 5.04E-09 | 5.04E-09 | 0.57 | 7.14E-13 | 0.909 | Cerebrospinal fluid levels of Alzheimer’s disease related proteins; Diastolic blood pressure; blood pressure medication; Self-reported hypertension; high blood pressure |
Brain_prefrontal_cortex | ACE | PsychENCODE | rs6504163 | 4.73E-07 | 4.73E-07 | 0.24 | 8.25E-08 | 0.995 | |
Brain_frontal_cortex | ACE | GTEx V8 | rs4291 | 3.25E-06 | 3.25E-06 | NA | 1.01E-05 | 0.991 | |
Brain_cerebellum | ACE | GTEx V8 | rs4292 | 1.33E-06 | 1.33E-06 | NA | 2.40E-06 | 0.995 | |
Brain_cortex | ACE | BrainMeta V2 | rs4292 | 1.05E-13 | 2.52E-11 | 0.18 | 2.40E-06 | 0.997 |