Table 2 Summary of phenotypic scanning and reverse causality detection on the candidate causative gene ACE and Alzheimer’s disease (Replication)
Tissue | Gene | Source | TopSNP | P.smr | P.smr_multi | P.value_HEIDI | Steiger filter | Co.localization.PPH4 | Previously reported association |
|---|---|---|---|---|---|---|---|---|---|
Blood | ACE | eQTLGen | rs4277405 | 5.49E-04 | 5.49E-04 | 0.522 | 2.06E-13 | 0.221 | Cerebrospinal fluid levels of Alzheimer’s disease related proteins; Diastolic blood pressure; blood pressure medication; Self-reported hypertension; high blood pressure |
Brain_prefrontal_cortex | ACE | PsychENCODE | rs6504163 | 8.42E-04 | 8.42E-04 | 0.821 | 7.33E-07 | 0.896 | |
Brain_frontal_cortex | ACE | GTEx V8 | rs4291 | 2.33E-03 | 2.33E-03 | NA | 4.16E-06 | 0.864 | |
Brain_cerebellum | ACE | GTEx V8 | rs4308 | 1.84E-03 | 1.84E-03 | NA | 4.04E-08 | 0.864 | |
Brain_cortex | ACE | BrainMeta V2 | rs4292 | 4.11E-04 | 6.87E-03 | 0.187 | 9.23E-07 | 0.014 |